PDK1(Phospho Ser241) Polyclonal Antibody, 20ul Protein Post-translational Modification Mutations in the gene cause

Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia

The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells

indicating a potential role for this protein in DNA repair

This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of these genes during mitochondrial biogenesis

Expressed specifically in the hippocampus and Purkinje cells of the brain

PDK1(Phospho Ser241) Polyclonal Antibody, 20ul Protein Post-translational Modification Mutations in the gene causeCatalytic activity: ATP + a protein = ADP + a phosphoprotein.,Phosphorylates and activates not only PKB AKT, but also PKA, PKC zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.,PTM: Phosphorylated on tyrosine and serine threonine. Phosphorylation on Ser 241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser 241,