BubR1 Polyclonal Antibody, 50ul 3D Culture The RNase III Drosha is

The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al

One of several members of the Ser/Thr protein kinase family

highly expressed in brain

It activates the urokinase-type plasminogen activator

brain and erythrocytes

BubR1 Polyclonal Antibody, 50ul 3D Culture The RNase III Drosha isBUB1B encodes a kinase involved in spindle checkpoint function. The protein (BUB1 mitotic checkpoint serine threonine kinase B)has been localized to the kinetochore and plays a role in the inhibition of the anaphase promoting complex cyclosome (APC C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.