NPRL2 Polyclonal Antibody, 50ul Cell Dissociation The protein encoded by this

The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro

The encoded protein belongs to a subfamily of intracellular serpins

and redistributes to the region of the spindle poles during mitosis

similarity:Contains 6 Kelch repeats

Reciprocal translocations between chromosomes 17 and 22

NPRL2 Polyclonal Antibody, 50ul Cell Dissociation The protein encoded by thisSuppresses Src dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr 9 Tyr 373 and Tyr 376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.