PTN13 Polyclonal Antibody, 20ul PCR Series Defects in this gene are

Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect

The protein is highly acidic

Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway

providing precise and efficient DNA cutting

Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms

PTN13 Polyclonal Antibody, 20ul PCR Series Defects in this gene areThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma