SPTC2 Rabbit Polyclonal Antibody, 100ul Lysosome DUSP14 contains the consensus DUSP

DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al

The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor| known as somatoliberin| which acts to stimulate growth hormone release from the pituitary gland

The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex

PGC (progastricsin) encodes an aspartic proteinase that belongs to the peptidase family A1

and it is able to suppress apoptosis induced by various signals

SPTC2 Rabbit Polyclonal Antibody, 100ul Lysosome DUSP14 contains the consensus DUSPThis gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase which consists of two different subunits is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal 5 prime phosphate dependent condensation of L serine and palmitoyl CoA to 3 oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I.