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GLP-1s can cost patients $12,000 per year out-of-pocket if not covered by their insurance provider, with spending on GLP-1s increasing more than 500% in the US between 2018 and 2023

However, this complexity can be a challenge

Although strict glycemic control has beneficial effects on microvascular complications (retinopathy, nephropathy or neuropathy), it does not seem to reduce the risk of cardiovascular disease, and it is associated with an increased risk of hypoglycemia in patients with DM2.3,6 Until recently, the antihyperglycemic drugs available have improved glycemic control, but without much benefits on cardiovascular and/or renal risk

GLP-1s work in part by suppressing appetite

Clinicians should consider taking patients off these drugs if they develop signs of heart failure