Artn Polyclonal Antibody, 20ul Virus Packaging Mutations in NOTCH4 may be

Mutations in NOTCH4 may be associated with schizophrenia

Several alternatively spliced transcript variants encoding different isoforms have been described for MED23

Cells from individuals with a mutation in this gene exhibited abnormalities in endoplasmic reticulum-dependent calcium signaling

An important paralog of this gene is ZNF169

The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane

Artn Polyclonal Antibody, 20ul Virus Packaging Mutations in NOTCH4 may beThis gene encodes a secreted ligand of the glial cell line derived neurotrophic factor (GDNF) subfamily and TGF beta (transforming growth factor beta) superfamily of proteins. Ligands of this family bind various TGF beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide linked homodimer.