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Estrogen regulates transcription factors STAT-1 and NF-kappB to promote inducible nitric oxide synthase and inflammatory responses

Dosing regimens in studies are tightly controlled and vary based on the research design, but generally vary between 18 mg weekly, in increments of 1mg with a maximum dose of 812mg

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Thats why its always best to talk to a medical provider before adding any supplement to your recovery routine, even if its sold over the counter