N4BP1 Polyclonal Antibody, 100ul Stepper The type I isozyme has

The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities

and may also function in sterol-mediated transcriptional regulation

A low level detected in the spleen and lymph node

A variant in this gene was associated with osteoarthritis

Phosphorylation at Ser-425 and Ser-428 is required for dissociation from the centrosome at the G2/M boundary

N4BP1 Polyclonal Antibody, 100ul Stepper The type I isozyme hasN4BP1 is a Protein Coding gene. NEDD4 Binding Protein 1 is a inhibitor of the E3 ubiquitin protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCHs substrates and impairing ubiquitination of substrates. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is ZC3H12C.