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Stoeltzing et al (109) reported that IGF-I selectively upregulates COX-2 through the MAPK/(ERK1/2) pathway in pancreatic cancer and that treatment with anti-IGF-IR antibodies can effectively inhibit IGF-IR and MAPK/ERK activation and reduce COX-2 expression in parental cells

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doi: 10.1016/j.neuropharm.2013.08.005 19 KalraSPDubeMGPuSXuBHorvathTLKalraPS

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