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MDM2 Polyclonal Antibody, 50ul[BT-AP05301] Drug Development and Evaluation proliferation and network formation by

SKU: 47532765970

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MDM2 Polyclonal Antibody, 50ul[BT-AP05301] Drug Development and Evaluation proliferation and network formation byMDM2 encodes a nuclear localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many

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Description

proliferation and network formation by endothelial cells as well as angiogenesis

Mutations in this gene have been associated with the hepatocerebral form of mitochondrial DNA depletion syndrome (MDDS)

The product of CLDN19 belongs to the claudin family

which is required for its activity

|disease:A chromosomal aberration involving CCND1 may be a cause of multiple myeloma

MDM2 Polyclonal Antibody, 50ul[BT-AP05301] Drug Development and Evaluation proliferation and network formation byMDM2 encodes a nuclear localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many

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