Collagen XVIII alpha 1(Cleaved-His1572) Rabbit Polyclonal Antibody, 100ul Site-directed Mutagenesis A mutation in this gene

A mutation in this gene was found in individuals with dementia with Lewy bodies

an arrangement which is thought to have evolved by a series of gene duplications

The SH2 (Src Homology 2) domain is a structurally conserved motif that contains two alpha helices and seven beta strands and is found in a variety of proteins that are involved in signal transduction throughout the cell

Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion

Collagen XVIII alpha 1(Cleaved-His1572) Rabbit Polyclonal Antibody, 100ul Site-directed Mutagenesis A mutation in this geneThis gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins extracellular matrix proteins that contain multiple triple helix domains (collagenous domains) interrupted by non collagenous domains. A long isoform of the protein has an N terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C terminal domain results in