TBK1 Polyclonal Antibody, 100ul Protein Modification This protein plays important roles

This protein plays important roles in the paracellular cation barrier of the distal renal tubule

Mutations in this gene are associated with nephronophthisis-14 and Joubert syndrome-19

The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele

WASF3 encodes a member of the Wiskott-Aldrich syndrome protein family

which functions downstream of the Ras family of membrane associated GTPases to which it binds directly

TBK1 Polyclonal Antibody, 100ul Protein Modification This protein plays important rolesThe NF kappa B (NFKB) complex of proteins is inhibited by I kappa B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The TANK binding kinase 1 encoded by TBK1 is similar to IKB kinases and can mediate NFKB activation in response