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Neuregulin-1 Polyclonal Antibody, 100ul[BT-AP05912] Site-directed Mutagenesis This protein efficiently cleaves only

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Neuregulin-1 Polyclonal Antibody, 100ul[BT-AP05912] Site-directed Mutagenesis This protein efficiently cleaves onlyPro neuregulin 1 membrane bound isoform encoded by NRG1 is a membrane glycoprotein that mediates cell cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue specific manner and differ significantly in their structure, and are classified as types

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Description

This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions| and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues| indicating that this protein is a major ISG15-specific protease

Pseudogenes are present on chromosomes 4

This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression

Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H)| a disorder of the peripheral nervous system

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain

Neuregulin-1 Polyclonal Antibody, 100ul[BT-AP05912] Site-directed Mutagenesis This protein efficiently cleaves onlyPro neuregulin 1 membrane bound isoform encoded by NRG1 is a membrane glycoprotein that mediates cell cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue specific manner and differ significantly in their structure, and are classified as types

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