NBPFG Rabbit Polyclonal Antibody, 50ul Antibody Humanization Regulator of G protein signaling

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins

Binds preferentially to the sequence 5'-TTCATTCATTCA-3'

Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites

Trichodentoosseous syndrome (TDO)

Additional variants are discussed in the literature

NBPFG Rabbit Polyclonal Antibody, 50ul Antibody Humanization Regulator of G protein signalingThis gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded to a lesser extent among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number