Nibrin Polyclonal Antibody, 50ul[BT-AP06022] Immune Cell Analysis The encoded protein contains several

The encoded protein contains several KH domains

|Contains 1 PA (protease associated) domain

Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium

the primary circadian pacemaker in the mammalian brain

|Contains 2 protein kinase domains

Nibrin Polyclonal Antibody, 50ul[BT-AP06022] Immune Cell Analysis The encoded protein contains severalMutations in NBN are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nibrin is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. NBN product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint activation.