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CD6 Polyclonal Antibody, 100ul[BT-AP01961] Culture Media Transcriptional repression by the encoded

SKU: 67996710180

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CD6 Polyclonal Antibody, 100ul[BT-AP01961] Culture Media Transcriptional repression by the encodedKLKB1 encodes a glycoprotein that participates in the surface dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations

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Description

Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex

with the last serine residue replaced by alanine

Transcripts initiating from the downstream promoter encode beta isoforms

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has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs

CD6 Polyclonal Antibody, 100ul[BT-AP01961] Culture Media Transcriptional repression by the encodedKLKB1 encodes a glycoprotein that participates in the surface dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations

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