PARP8 Polyclonal Antibody, 20ul Gloves The protein encoded by this

The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit

An important paralog of this gene is MID1

The encoded protein is also a candidate tumor suppressor protein| and aberrant promoter methylation of this gene may play a role in cervical cancer

They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes

An important paralog of this gene is SNRNP200

PARP8 Polyclonal Antibody, 20ul Gloves The protein encoded by thisCatalytic activity: NAD(+) + (ADP D ribosyl)(n) acceptor = nicotinamide + (ADP D ribosyl)(n+1) acceptor.,PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence Contaminating sequence. Potential poly A sequence.,Contains 1 PARP catalytic domain.,