53BP1 Polyclonal Antibody, 50ul[BT-AP00040] Centrifugal Filter class II and class III

class II and class III

Multiple transcript variants encoding different isoforms have been found for PHACTR4

Alternative splicing of TOP2B results in two transcript variants

followed by five EGF‑like domains (aa 204‑451)

such that the alleles were once thought to represent two separate gene

53BP1 Polyclonal Antibody, 50ul[BT-AP00040] Centrifugal Filter class II and class IIIThe p53 binding proteins 53BP1 and 53BP2 (Bbp) bind to the central DNA binding domain of wild type p53, but do not bind mutant p53. The central DNA binding domain of p53 is required for site specific DNA binding and is frequently mutated in malignant tumors. Binding of 53BP1 to the L3 loop of p53 and of 53BP2 to the L2 loop of p53 confirms that the loop is dependent on p53 conformation. Site specific binding also suggests that 53BP1 and 53BP2 are