Lamin B1 Polyclonal Antibody, 100ul[BT-AP04936] Antibodies Alternatively spliced transcript variants encoding

Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene

Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance

and vision

Binding of the encoded protein by filamin A targets it to sites of membrane protrusion

induction:Down-regulated in many primary skin melanomas

Lamin B1 Polyclonal Antibody, 100ul[BT-AP04936] Antibodies Alternatively spliced transcript variants encodingLMNB1 encodes one of the two B type lamin proteins and is a component of the nuclear lamina. A duplication of LMNB1 is associated with autosomal dominant adult onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants.