IKappaB-Epsilon Polyclonal Antibody, 50ul ROS/Nitric Oxide Detection The protein encoded by CBF2alpha

The protein encoded by CBF2alpha (runt related transcription factor 1

It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination

the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53

also known as inherited thrombophilia

At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed

IKappaB-Epsilon Polyclonal Antibody, 50ul ROS/Nitric Oxide Detection The protein encoded by CBF2alphaThe protein encoded by NFKBIE binds to components of NF kappa B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF kappa B by making it available to translocate to the nucleus.