p53(Phospho Ser20) Polyclonal Antibody, 50ul Hybridoma Antibody Sequencing Alternatively spliced transcript variants encoding

Alternatively spliced transcript variants encoding distinct isoforms have been described

The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration

An important paralog of this gene is LOC81691

This protein is a secreted endocrine factor that functions as a major metabolic regulator

gorilla and orangutan orthologous proteins do not exist

p53(Phospho Ser20) Polyclonal Antibody, 50ul Hybridoma Antibody Sequencing Alternatively spliced transcript variants encodingThis gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni syndrome.