Human Cytosolic purine 5'-nucleotidase, NT5C2 ELISA Kit, 48T Diagnostic Probes & Oligos The erb-b2 receptor tyrosine kinase

The erb-b2 receptor tyrosine kinase 4 binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation

Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma

Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed: 10557084)

This gene is regarded as a potential tumor suppressor gene

May also phosphorylate FXYD1/PLM which is able to induce chloride currents

Human Cytosolic purine 5'-nucleotidase, NT5C2 ELISA Kit, 48T Diagnostic Probes & Oligos The erb-b2 receptor tyrosine kinase