TGR5 Polyclonal Antibody, 50ul Rotator The cystatin locus on chromosome

The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes

|subunit:When phosphorylated| interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2| GRAP| GRAP2| PLCG1 and PLCG2

The ratio of type 1: type 2 chains changes during embryogenesis

Mutations in SGCA result in type 2D autosomal recessive limb-girdle muscular dystrophy

and ubiquitylates synphilin-1

TGR5 Polyclonal Antibody, 50ul Rotator The cystatin locus on chromosomeGPBAR1 encodes a member of the G protein coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids.