Phospho-APC (S2054) Polyclonal Antibody, 50ul DNA Fragments The SIX homeobox 2 is

The SIX homeobox 2 is a transcription factor which

RAB10 belongs to the RAS (see HRAS| MIM 190020) superfamily of small GTPases

Binding occurs as a ternary complex of methionyl-tRNA

and a C-terminal PDZ domain-binding motif

Loss of cadherins may be associated with cancer formation

Phospho-APC (S2054) Polyclonal Antibody, 50ul DNA Fragments The SIX homeobox 2 isAPC encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre malignant disease that usually progresses to malignancy. Disease associated mutations tend to be clustered in a small region designated the