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Dysfunction of photoreceptors in dry AMD and Stargardt disease (SD) is associated with defects of atRAL clearance ( 2+ overload, tripeptide glutathione (GSH) depletion, damaged mitochondria and lipid peroxidation in photoreceptors via ACSL4 elevation, system Xc() inhibition and MT-CO2 activation, resulting in photoreceptor ferroptosis and dysfunction ( 2.2 Retinal degeneration induced by blue light or others Retinal photoreceptors, mainly including rod and cone cells, are a special type of neuroepithelial cells with light transduction ability with the function of converting light signals into neural signals (Zhao and Peng, 2021)

Salinas et al 27 The traditional treatment of vitamin B 12 deficiency is the intramuscular injection of cyanocobalamin, generally, 1 mg/d for 1 week, followed by 1 mg/wk for 1 month, and then 1 mg every 1 or2 months ad perpetuum

Wu YL, Lu S, Lu Y, Zhou J, Shi YK, Sriuranpong V, et al

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