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The overall timeline to meaningful results should not change substantially with split dosing since total drug exposure remains equivalent

They are prescription medications, originally developed for type 2 diabetes, now widely used in medically supervised weight management

Is bariatric surgery more effective than GLP-1 medications for long-term weight loss

doi: 10.1172/jci.insight.133429 171 ZhangFTongYSuNLiYTangLHuangLet al

The participant must be at least 18 years old and: Have a BMI of 35 or greater, or Have a BMI of 30 or greater with a diagnosis of diastolic heart failure, uncontrolled hypertension or chronic kidney disease Stage 3a or higher, or Have a BMI of 27 or greater with pre-diabetes, previous myocardial infarction or stroke, or symptomatic peripheral artery disease

The role of Tirzepatide, dual GIP and GLP-1 receptor agonist, in the management of type 2 diabetes: the SURPASS clinical trials