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Renal Impairment The dosing requirements for SYMLIN are not altered in patients with mild (creatinine clearance [Cl Cr ] 60-89 mL/min), moderate (Cl Cr 30-59 mL/min) or severe renal impairment (Cl Cr 15-29 mL/min)

Determinations Blood samples were drawn from patients before and at the end of each cycle

Similarly, UA defends against oxidative stress caused by focal cerebral ischemia/reperfusion by activating the Nrf2 pathway and upregulating the expression of BDNF and NGF [172]