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Ondansetron (48 mg as needed) is a serotonin 5-HT3 receptor antagonist that can be effective for GLP-1 agonist-related symptoms, though it may cause constipation, headache, and can prolong the QT interval in susceptible individuals

it has been used to treat metabolic syndrome and AS for a long time (94)

A recent study by Lius team demonstrated that the broad-spectrum DUB inhibitor palladium pyrithione complex (PdPT) promote GPX4 degradation, but proteasome inhibitor bortezomib reverses its effect (Yang L