WZ4002 Size:10mg solid ERRα overexpression further aggravates PAN-induced

ERRα overexpression further aggravates PAN-induced apoptosis

InChi: InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7

InChi: InChI=1S/C24H27N5O3/c30-22(28-32)15-9-1-2-10-16-25-23(31)19-17-26-24(27-18-19)29(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8

33(9):689-97

InChi: InChI=1S/C15H18N2

WZ4002 Size:10mg solid ERRα overexpression further aggravates PAN-inducedWZ4002 is EGFR inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) which is detected in 50% of clinically resistant patients to gefitinib or erlotinib. WZ4002 has a basic chemical framework (covalent pyrimidine) which is different from that of other EGFR inhibitors. This agent is 30 to 100 fold more potent against EGFR T790M, and up to 100 fold less potent against wildtype EGFR, than quinazoline based EGFR inhibitors (HKI 272 and CL