Epetraborole hydrochloride - CAS# 1234563-16-6 size:2mg solid 348(2):167-76

348(2):167-76

azakenpaullone

8E)-N-(4-hydroxyphenyl)-3

It has >700-fold selectivity over the BET family and 200-fold over the highly homologous bromodomain-containing protein 7 (BRD7)

the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer

Epetraborole hydrochloride - CAS# 1234563-16-6 size:2mg solid 348(2):167-76Epetraborole hydrochloride, CAS No. 1234563 16 6, also known as GSK2251052 and AN3365, is a potent and selective leucyl tRNA synthetase inhibitor. Epetraborole was in development for the treatment of infections caused by multidrug resistant Gram negative pathogens. GSK2251052 is a novel boron containing antibiotic that inhibits bacterial leucyl tRNA synthetase. All Clostridium perfringens strains had GSK2251052 MICs of >32 g ml. Product information