KY02111 - Wnt Inhibitor. CAS# 1118807-13-8 306 Cyclopamine was administered at 50

Cyclopamine was administered at 50 mg/kg by subcutaneous injection once per day in tumor xenograft mouse model

Discovery of I-BRD9

is a potent and selective small molecule that enhances hepatocyte functions and promotes the differentiation and maturation of iPSC-derived hepatocytes toward a more mature phenotype in vitro

It has >700-fold selectivity over the BET family and 200-fold over the highly homologous bromodomain-containing protein 7 (BRD7)

2109424-53-3 (SAG(trans-cis) HCl)

KY02111 - Wnt Inhibitor. CAS# 1118807-13-8 306 Cyclopamine was administered at 50KY02111, CAS No. 1118807 13 8, is a potent and selective Wnt signaling pathway inhibitor discovered by a cell based screening, which promotes differentiation of hESCs iPSCs to cardiomyocytes when used at the second stage of differenitation. Sequential use of CHIR99021 (in the first stage to trigger mesoderm induction of hESCs iPSCs) followed by KY02111 (or XAV939, another Wnt signaling inhibitor) produced robust cardiac differentiation of hESCs iPSCs