semaglutide shipped warm Storage: Does Compounded Semaglutide Need Refrigeration? – PlexusDx First Strive shipment arrived warm

Results were published in the New England Journal of Medicine in 2025

doi: 10.1186/s12933-022-01511-x 261 RenJLvCWangJ

If your compound is accidentally left out of the fridge , brief periods at room temperature (up to a few hours) are generally acceptable

OSA, hyperlipidemia, CVD) Main exclusion criteria Diabetes HbA1c 6.5% Previous obesity surgery History of chronic pancreatitis Acute pancreatitis within 180 days Baseline characteristics Average age 46 years Female sex - 74% Average weight - 231 lbs (105 kg) Average BMI - 38 Randomized treatment groups Group 1 (1306 patients): Wegovy 2.4 mg subcutaneously once weekly Group 2 (655 patients): Placebo Wegovy was started at a dose of 0.25 mg once weekly and increased every 4 weeks over a period of 16 weeks to a target dose of 2.4 mg once weekly All patients also received diet and exercise counseling Coprimary endpoints were the percentage change in body weight from baseline to week 68 and achievement of a reduction in body weight of 5% or more from baseline to week 68 Primary outcome: Results In participants with overweight or obesity, 2.4 mg of semaglutide once weekly plus lifestyle intervention was associated with sustained, clinically relevant reduction in body weight

doi: 10.1056/NEJMoa0806470 4 HolmanRRPaulSKBethelMANeilHAMatthewsDR

Overall, 36% were White, 35% were Asian, 25% were American Indians/Alaska Natives, and 5% were Black or African American