SB431542 - TGF-beta Inhibitor. CAS# 301836-41-9 Catalog No.:M60015-2S CAS Number: 345630-40-2

CAS Number: 345630-40-2

Knöll R

CAS Number: 844499-71-4

S3I-201 inhibits breast carcinoma MDA-MB-435

Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II

SB431542 - TGF-beta Inhibitor. CAS# 301836-41-9 Catalog No.:M60015-2S CAS Number: 345630-40-2SB 431542, CAS No. 301836 41 9, is a potent and selective inhibitor of TGF type I receptors ALK5 (IC50 ~94 nM), ALK4 (IC50 ~140 nM) and ALK7. It has no activities on the other ALK family members such as ALK2, ALK3 and ALK6, nor on components of the ERK, JNK, and p38 MAP kinase pathways. It specifically blocks Smad2 signaling, modulating gene expression related to EMT. In several publications SB 431542 has been used to enhance iPSC reprogramming,