Vinflunine Size:Solid 2 mg with much higher IC50 values

with much higher IC50 values (40 nM–170 nM)

PubMed Central PMCID: PMC3968083

PubMed PMID: 25726556

Combination of menadione and DMXAA leads to an increase in the antiproliferative activity of DLD-1 cells

CAS Number: 2719-05-3

Vinflunine Size:Solid 2 mg with much higher IC50 valuesVinflunine is a bi fluorinated derivative of the semi synthetic vinca alkaloid vinorelbine with antitubulin, antineoplastic, and antiangiogenic activities. Vinflunine inhibits tubulin assembly without any stablization of assembled microtubules at concentrations comparable to those of other vinca alkaloids such as vincristine, vinblastine and vinorelbine; this effect on microtubule dynamics results in cell cycle arrest in mitosis and apoptosis.