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Use a physician-led clinic that dispenses only through a named, licensed 503A or 503B compounding pharmacy, requires a valid prescription after evaluation, and can provide certificates of analysis showing third-party testing

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Studies have reported decreased AP-1 expression in dopaminergic neurons, less reduction in ROS content, and improved dyskinesia in PD mice in the MPTP model of TLR4-knockout (KO) mice, suggesting that TLR4 plays a key role in the pathogenesis of PD (Heidari et al., 2022)

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This prioritization is primarily due to the well-established ability of GLP-1 RAs to reduce the risk of major adverse cardiovascular events, as evidenced by large-scale clinical trials

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