sirtinol - CAS# 410536-97-9 217 Flanagan ME

Flanagan ME

Conkling PR

1380548-02-6

Go6983 was used at 1-5 µM final concentration in vitro and in cellular assays

It binds to the enzyme active site and inhibits DNMT enzymatic activity with an IC50 ~ 115 nM

sirtinol - CAS# 410536-97-9 217 Flanagan MESirtinol, CAS No. 410536 97 9, is a SIRT inhibitor. Sirtinol significantly increased the acetylation of p53, which has been reported to be a target of SIRT1 2. Sirtinol significantly increased the G1 phase of the cell cycle. Product information CAS Number: 410536 97 9 Molecular Weight: 394. 47 Formula: C26H22N2O2 Synonym: Sirtinol 2 [(2 Hydroxynaphthalen 1 ylmethylene)amino] N (1 phenethyl)benzamide 2 {[(2 hydroxy 1 naphthyl)methylene]amino} N (1