BMS-911543 - CAS# 1271022-90-2 Size:Solid 10 mg Smiles: CN(CCOC(=O)C1C(C(C(=O)OC)=C(C)NC=1C)C1=CC(=CC=C1)N(=O)=O)CC1C=CC=CC=1
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BMS-911543 - CAS# 1271022-90-2 Size:Solid 10 mg Smiles: CN(CCOC(=O)C1C(C(C(=O)OC)=C(C)NC=1C)C1=CC(=CC=C1)N(=O)=O)CC1C=CC=CC=1BMS 911543 is an orally available small molecule targeting a subset of Janus associated kinase (JAK) with potential antineoplastic activity. JAK2 inhibitor BMS 911543 selectively inhibits JAK2, thereby preventing the JAK STAT (signal transducer and activator of transcription) signaling cascade, including activation of STAT3. This may lead to an induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or
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