ML-329 - CAS# 19992-50-8 072 LY-3090314 enhances the efficacy of

LY-3090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer cell lines in vitro

CAS Number: 524684-52-4

ALK3 or ALK6-induced Smad signaling

Potent antitumor activity of HSP90 inhibitor AUY922 in adrenocortical carcinoma

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ML-329 - CAS# 19992-50-8 072 LY-3090314 enhances the efficacy ofML 329, CAS No. 19992 50 8, is an inhibitor of the microphthalmia associated transcription factor (MITF) pathway with an IC50 value of 1. 2 M for promoter activity of the MITF target gene TRPM 1. ML 329 showed specific activity against the MITF dependent cells, primary melanocytes but no effect on the viability in A375 cells. ML 329 reduced the expression of multiple MITF target genes, including pigment related genes and the cell cycle regulator CDK2.