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R-112 f Histone Demethylase NC[C@H]1OB(O)C2=C1C=CC=C2OCCCO
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R-112 f Histone Demethylase NC[C@H]1OB(O)C2=C1C=CC=C2OCCCOR112 is a Syk inhibitor. R112 inhibited degranulation induced by anti IgE cross linking in mast cells (tryptase release, effective concentration for 50% inhibition [EC(50)] = 353 nmol L) or basophils (histamine release, EC(50) = 280 nmol L), and by allergen (dust mite) in basophils (histamine release, EC(50) = 490 nmol L). R112 also blocked leukotriene C4 production and all proinflammatory cytokines tested. Subsequent molecular characterization
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