TAS-103 dihydrochloride l maleate Sanapala KR

Sanapala KR

CAS Number: 63302-99-8

combination treatment with Everolimus and trastuzumab significantly decreases the xenograft tumor size (410

or no treatment

Smiles: NC1N=C2C(N=CN2[C@@H]2C[C@H](CO)C=C2)=C(NC2CC2)N=1

TAS-103 dihydrochloride l maleate Sanapala KRTAS 103, also known as BMS 247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models. TAS 103 has been reported to be a potent topoisomerase II poison. TAS 103 showed the strongest antitumor activity among the conventional anticancer agents for colorectal cancer (p<0. 05). The combination with CDDP augmented the antitumor activity of TAS 103 (p<0. 05), indicating that CDDP is one of the most potent candidates