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SW033291 - 15-PGDH Inhibitor. CAS# 459147-39-8 Catalog No.:M60298-10S Epub 2011 Mar 31

SW033291 - 15-PGDH Inhibitor. CAS# 459147-39-8 Catalog No.:M60298-10S Epub 2011 Mar 31

Name: SW033291 - 15-PGDH Inhibitor. CAS# 459147-39-8 Catalog No.:M60298-10S Epub 2011 Mar 31
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SW033291 - 15-PGDH Inhibitor. CAS# 459147-39-8 Catalog No.:M60298-10S Epub 2011 Mar 31SW033291, CAS No. 459147 39 8, is a highly potent and selective inhibitor of 15 PGDH enzyme with IC50 1. 5 nM, can increase prostaglandin PGE2 levels in bone marrow and other tissues. It inhibits 15 PGDH with noncompetitive pattern. Treatment of A549 cells with SW033291 increased PGE2 levels by 3. 5 fold at 500 nM, with EC50 value of ~75 nM. SW033291 accelerates hematopoietic recovery in mice receiving a bone marrow transplant. It also promotes tissue

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Description

Epub 2011 Mar 31

Epub 2015 Apr 21

A single dose of ABT-199 in three patients with refractory chronic lymphocytic leukemia resulted in tumor lysis within 24 h

Formula: C13H12Cl2N4

Smiles: CC(C)C1C(=O)N2N=CC(C#N)=C2NC=1C1C=CC=CC=1

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