CUDC-101 - HDAC/EGFR/HER2 Inhibitor. CAS# 1012054-59-9 Catalog No.:M60092-2S (2008) Oncogene

(2008) Oncogene

Stat1•Stat3

4-DPCA is found to be effective at inhibiting collagen deposition within and on the outer surface of the disc

HLY78 may weaken the autoinhibition of Axin

Growth response of human colorectal tumour cell lines to treatment with afatinib (BIBW2992)

CUDC-101 - HDAC/EGFR/HER2 Inhibitor. CAS# 1012054-59-9 Catalog No.:M60092-2S (2008) OncogeneCUDC 101, CAS No. 1012054 59 9, is a potent multi target inhibitor targeting HDAC, EGFR and HER2 with IC50 of 4. 4 nM, 2. 4 nM, and 15. 7 nM, respectively. It is specific for class I and class II HDACs, not for class III Sir type HDACs, and has > 50 fold selectivity against other protein kinases. CUDC 101 displays broad antiproliferative activity in many human cancer cell types with IC50 of 0. 04 0. 80 M, exhibiting a higher potency than erlotinib,