CP-690550 - JAK Inhibitor. CAS# 477600-75-2 0273 also known as Luminespib

also known as Luminespib

is a selective Rev-Erbα/β agonist that increases wakefulness

PRT4165 was used at 10-50 µM final concentration in various in vitro assays

Su-11274 increases tumorigenicity and enriched for melanoma-initiating cells by bioenergetic modulation

4-tetrahydro-[1

CP-690550 - JAK Inhibitor. CAS# 477600-75-2 0273 also known as LuminespibCP 690550, CAS No. 477600 75 2, is a potent and selective JAK inhibitor currently in clinical trials for rheumatoid arthritis (RA) and other autoimmune disease indications. It inhibits recombinant human JAK1 (IC50 ~ 3. 2 nM), JAK2 (IC50 ~4. 1 nM), and JAK3 (IC50 ~1. 6 nM). In cellular assays CP 690550 showed potent effects in the IL 2 blast proliferation assay (IC50 ~11 nM, mediated via JAK1 and JAK3) and HU03 cellular specificity assay (IC50 ~324 nM,