OTSSP167 - CAS# 1431697-89-0 Catalog No.:M9991-10 The IC50 of Halofuginone for

The IC50 of Halofuginone for global protein synthesis is 22

[Epub ahead of print] PubMed PMID: 27989726

These inhibitory effects of CH-223191 prevented the expression of cytochrome P450 enzymes

CAS Number: 134678-17-4

4-d]pyrimidin-4-one

OTSSP167 - CAS# 1431697-89-0 Catalog No.:M9991-10 The IC50 of Halofuginone forOTSSP167, also known as OTS167, is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity. Upon administration, OTS167 binds to MELK, which prevents both MELK phosphorylation and activation; thus inhibiting the phosphorylation of downstream MELK substrates. This may lead to an inhibition of both cell proliferation and survival in MELK expressing tumor cells. Product information CAS