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HI-TOPK-032 - TOPK inhibitor. CAS# 487020-03-1 stat providing a strong rationale for

HI-TOPK-032 - TOPK inhibitor. CAS# 487020-03-1 stat providing a strong rationale for

Name: HI-TOPK-032 - TOPK inhibitor. CAS# 487020-03-1 stat providing a strong rationale for
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SKU: 56440748498
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SKU: 56440748498

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HI-TOPK-032 - TOPK inhibitor. CAS# 487020-03-1 stat providing a strong rationale forHI TOPK 032 is a potent and selective TOPK inhibitor. HI TOPK 032 also reduces ERK RSK phosphorylation, regulates of the abundance of p53, cleaved caspase 7, and cleaved PARP, and induces apoptosis in cancer cells. In vitro, HI TOPK 032 strongly suppressed TOPK kinase activity but had little effect on extracellular signalregulated kinase 1 (ERK1), c junNH2kinase 1, or p38 kinase activities. HI TOPK 032 also inhibited anchorage dependent and

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providing a strong rationale for their combined use in the clinic

PubMed PMID: 24794912

309(3):E302-10

induces growth inhibition and apoptosis in human gastric cancer cells

is a potent inhibitor of MEK5 (IC50 = 4

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