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PF-8380 Catalog No.:M10681-10 Chemical Name: calcium 2-benzyl-4-((3aR

PF-8380 Catalog No.:M10681-10 Chemical Name: calcium 2-benzyl-4-((3aR

Name: PF-8380 Catalog No.:M10681-10 Chemical Name: calcium 2-benzyl-4-((3aR
Brand: armz-ageddon.com
SKU: 56576659099
Price: 108.90 USD
Availability: InStock
Rating: 4.6435 (25 reviews)

SKU: 56576659099

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PF-8380 Catalog No.:M10681-10 Chemical Name: calcium 2-benzyl-4-((3aRPF 8380 is a potent autotaxin inhibitor with an IC(50) of 2. 8 nM in isolated enzyme assay and 101 nM in human whole blood. PF 8380 has adequate oral bioavailability and exposures required for in vivo testing of autotaxin inhibition. Autotaxin's role in producing LPA in plasma and at the site of inflammation was tested in a rat air pouch model. The specific inhibitor PF 8380 , dosed orally at 30 mg kg, provided >95% reduction in both plasma and air

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Description

Chemical Name: calcium 2-benzyl-4-((3aR

Verhoest PR

Salas-Puig X

Formula: C6H11AuO5S

8a-dimethyl-2-methylidene-decahydronaphthalen-1-yl]ethylidene}-4-hydroxyoxolan-2-one

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