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Three protocols cover most joint pain scenarios

However, this assessment comes from limited data

This higher dose can be administered as a single 100mg injection in the morning or split into two 50mg doses taken 12 hours apart (morning and afternoon)

One possible explanation is that low serum vitamin B12 levels would trap folate as 5-methyltetrahydrofolate, prevent the generation of methionine from homocysteine, and therefore reduce protein synthesis and lean tissue deposition