DMH-1 - CAS# 1206711-16-1 0197 34(1):58-61

34(1):58-61

It suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation

is a fibroblast growth factor receptor 4 (FGFR4) inhibitor potentially for the treatment of hepatocellular carcinoma and cholangiocarcinoma

competitive and cell permeable prolyl 4-hydroxylase (P4H) inhibitor

TAK-960 treatment causes accumulation of G2-M cells

DMH-1 - CAS# 1206711-16-1 0197 34(1):58-61DMH 1, CAS No. 1206711 16 1, is a second generation small molecule BMP inhibitor based on dorsomorphin. DMH 1 effectively inhibits the bone morphogenic protein (BMP) ALK2 receptor (IC50 = 108 nM). Treatment with DMH1 reduced lung metastasis and the tumors were less proliferative and more apoptotic. In the surrounding tumor microenvironment, treatment with DMH1 altered fibroblasts, lymphatic vessels and macrophages to be less tumor promoting. These