Safinamide tatoside A selective and cell permeable HDAC3

selective and cell permeable HDAC3 inhibitor

(http://en

CN(CC1=CC=CC=C1N(CCO)S(=O)(=O)C1C=CC(=CC=1)OC)C/C=C/C1C=CC(Cl)=CC=1

Smiles: CC1(C)C=CC2=CC(CCN3C4=CC=CC=C4C4=CC=CC=C34)=CC(C=O)=C2O1

TAK-779 did not affect production of IL-12 by antigen-presenting cells

Safinamide tatoside A selective and cell permeable HDAC3Safinamide, also known as FCE 26743 and EMD 1195686, is a drug indicated for the treatment of Parkinson's disease with multiple methods of action. Potential additional uses might be restless legs syndrome (RLS) and epilepsy. Safinamide is a reversible and selective monoamine oxidase B inhibitor, reducing degradation of dopamine, and a glutamate release inhibitor. It also inhibits dopamine reuptake. Additionally, safinamide blocks sodium and calcium